The Effect of Negative Pressure Wound Therapy (NPWT) on Diabetic Ulcer Wound Healing (Literature Review)

Abstract

Diabetes mellitus is a problem that constantly occurs in Indonesia and the world until now. Various
complications arise if not treated and controlled properly such as diabetic ulcers. The main goal of diabetic ulcer
treatment is to achieve healing as quickly as possible. Many wound care techniques are currently developing along
with technological developments, one of which is Negative Pressure Wound Therapy/NPWT. This study was
conducted to determine the effect of NPWT intervention on diabetic ulcer healing specifically. Scopus, Pubmed,
Sage, ProQuest were used to find articles that matched the inclusion and exclusion criteria, then reviewed. There
was an effect of giving NPWT as evidenced by a decrease in the wound area, leukocyte count, and Ang2 levels,
an increase in the number of EPCs with a significant value of p<0.05). The use of NPWT attracts excess exudate
by applying negative pressure to the wound so that the wound fluid is reduced and the wound heals faster. NPWT
is safe to use on diabetic ulcers, especially to help reduce exudate, wound area, and depth, accelerate healing time,
increase the number of growth factors in wound tissue regeneration. Further research is needed to prove other
clinical benefits of using NPWT